منابع مشابه
Kidney and Phosphate Metabolism
The serum phosphorus level is maintained through a complex interplay between intestinal absorption, exchange intracellular and bone storage pools, and renal tubular reabsorption. The kidney plays a major role in regulation of phosphorus homeostasis by renal tubular reabsorption. Type IIa and type IIc Na(+)/Pi transporters are important renal Na(+)-dependent inorganic phosphate (Pi) transporters...
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The six carbons that comprise the inositol ring can be phosphorylated in a combinatorial manner, generating a truly astonishing range of inositol phosphates and inositol lipids. Yet, somehow, the cell can distinguish and utilize several of these metabolites to specifically regulate a variety of signal transduction processes. These important actions have infiltrated so many areas of cell biology...
متن کاملMetabolism of Hexose Phosphate Esters
Shortly after the discovery of insulin, it was shown by a number of investigators (Wigglesworth, Woodrow, Smith & Winter, 1923; Harrop & Benedict, 1924; Bollinger & Hartman, 1925) that there was a decrease in the inorganic phosphorus content of the blood in normal and diabetic animals following the injection ofinsulin. These observations first led to the hypothesis that insulin was concerned wi...
متن کاملChloroquine Phosphate Metabolism and Gender-Based Phenotypic Analysis among Healthy Subjects’ Urine Following Oral Administration
The advent of chloroquine promising activity against the COVID-19 is novel and as such, it is imperative to thoroughly understand and determine the rate at which individual body systems handle the drug. Chloroquine a known antimalarial drug belongs to the chemical class of 4-aminoquinolines. The aim of the study was to analyze Chloroquine and its metabolite in biological fluids of healthy subje...
متن کاملDysregulation of phosphate metabolism and conditions associated with phosphate toxicity.
Phosphate homeostasis is coordinated and regulated by complex cross-organ talk through delicate hormonal networks. Parathyroid hormone (PTH), secreted in response to low serum calcium, has an important role in maintaining phosphate homeostasis by influencing renal synthesis of 1,25-dihydroxyvitamin D, thereby increasing intestinal phosphate absorption. Moreover, PTH can increase phosphate efflu...
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ژورنال
عنوان ژورنال: Calcified Tissue International
سال: 2020
ISSN: 0171-967X,1432-0827
DOI: 10.1007/s00223-020-00727-x